European Network for the Study of Cholangiocarcinoma (ENS-CCA) | European Cholangiocarcinoma Network
The Disease
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. It is the second most common primary liver tumor type and accounts for around 3% of all gastrointestinal cancers. CCA is a very deadly disease due to its aggressiveness, late diagnosis and treatment refractory nature. The incidence and mortality rates are increasing worldwide and the therapeutic options are limited. Radiotherapy, chemotherapy (palliative), surgical resection (available for 10-30% of cases) and/or liver transplantation are options only for only a few patients who meet certain criteria. After curative surgery more than 50% of patients recur within 12 months. Therefore, there is increasing interest in understanding the molecular mechanisms involved in the pathogenesis of this cancer type and in identifying new targets for therapy. Moreover, good specific diagnostic and prognostic markers for CCA are still needed.
Our Network
European Network for the Study of Cholangiocarcinoma (ENS-CCA) is a network of active researchers with a broad interest in CCA, and biliary tract cancer in general, which have significantly contributed to the study into the pathophysiology of the biliary tree and development/onset of CCA, pursuing basic, translational and clinical research in an effort to identify treatment options with successful outcome for this type of cancer. For years, our laboratories have generated, together with our colleagues, many of the key advances in this field. ENS-CCA include research groups located in 15 European countries with interest in CCA from Basic, Translational and Clinical research.
Coordinator
Dr Angela Lamarca
Steering committee members
Dr Pedro Rodrigues
Prof Ana Lleo
Dr Jerzy Kotlinowski
Dr Colm O'Rourke
Dr Anna Saborowski
Dr Marta Afonso
Steering committee 2024-2026
Coordinator: Dr Luke Boulter
Members: Dr Angela Lamarca, Dr Stephanie Roessler, Dr Pedro Rodrigues, Dr Ana Lleo, Dr Jerzy Kotlinowski
Steering committee 2022-2024
Coordinator: Dr Chiara Braconi
Members: Dr Guido Carpino, Dr Jesper B. Andersen, Dr Rocio I.R. Macias, Dr Angela Lamarca, Dr Stephanie Roessler, Dr Luke Boulter
Steering committee 2016-2022
Coordinator: Dr Jesus M. Banales
Members: Dr Vincenzo Cardinale, Prof Domenico Alvaro, Dr Guido Carpino, Dr Chiara Braconi, Dr Jesper B. Andersen, Dr Rocio I.R. Macias
Founding members
Jesus M. Banales, Vincenzo Cardinale, Prof Domenico Alvaro, Prof Jose JG Marin, Guido Carpino, Jesper B. Andersen and Rocio I.R. Macias
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