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Perineural invasion is a prognostic factor in cholangiocarcinoma, regardless of anatomical location: a systematic review and meta-analysis: Perineural invasion in cholangiocarcinoma prognosis

Conti S, Tissera NS, Castet F, Basagaña-Farrés M, Teresa Salcedo M, Pando E, Dopazo C, Caritá L, Turpin A, Navarro GarcésV, Villacampa G,Macarulla T, Tian TV
JHEP Reports 5 February 2026, 101770, doi.org/10.1016/j.jhepr.2026.101770
2026 
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Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses

Han Y, Byun J, VanLith CJ, Cooley MA, Shaw VR, Hatia RI, Ahmed FY, Giama NH, Ali HM, Campbell NA, Hassan M, Andersen JB, Ankoma-Sey V, Banales JM, Bujanda L, Bathe OF, Bekaii-Saab TS, Borad MJ, Björkström NK, Chan CHF, Cleary SP, Cornillet M, Folseraas T, Galle PR, Genkinger JM, MacInnis RJ, Gores GJ, Goyal L, Houlston RS, Ilyas SI, Javle M, Johansen JS, Christensen TD, Kamath AS, Kelley RK, Khan SA, Kim RD, Kwee SA, Lamarca A, Lammert F, LaRusso NF, Lindsey S, Macias RIR, Malhi H, Patel TC, Permuth JB, Reeves HL, Rossi S, Sanchez W, Smoot RL, Swerdlow AJ, Tran Cao HS, Valle JW, Weinmann A, Weinmann-Menke J, Wong LL, Zhang X, Zimmer V, Zhu AX, Lazaridis KN, Juran BD, Jalal P, Knox JJ, Hutchinson A, Hicks B, Koshiol JE, Chanock SJ, Hassan MM, Amos CI, McGlynn KA, Roberts LR
Hepatology. 2026 Feb 2. doi: 10.1097/HEP.0000000000001699
2026 
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Stroma-driven inter- and intratumoral heterogeneity of PD-L1 expression in cholangiocarcinoma: Implications for biomarker development and prognostic evaluation

Saborowski A, Peters S, Zhao J, Marhenke S, Volk V, Reschke JS, Korosteleva A, Yi D, Reineke-Plaaß T, Augustin J, Tran DDH, Ibarra-Arellano MA, Schapiro D, Lemke S, Krönke N, Rapposelli IG, Segatto O, Bathon M, Gerdes C, Calderaro J, Kolch W, Zhernovkov V, Feuerhake F, Vogel A
Hepatology. 2026 Jan 26. doi: 10.1097/HEP.0000000000001686
2026 
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Loss of Aquaporin-1 in Tumor Cells Fosters Intrahepatic Cholangiocarcinoma Progression

Gaspari C, Beaupere C, Richard S, Peixoto E, Lekbaby B, Minini M, Dubravcic B, Vaquero J, Vallette M, Arbelaiz A, Janona M, Louis C, Le Gall P, Coulouarn C, Marrone J, Lloréns JA, Marinelli RA, Gradilone SA, Fouassier L
Am J Pathol. 2025 Nov 7:S0002-9440(25)00406-7. doi: 10.1016/j.ajpath.2025.10.007
2025 
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Epithelial to Mesenchymal Transition Transcriptional Regulator ZEB1 in Liver Cancer: Oncogenic Roles and Therapeutic Potential

Gonzalez-Sanchez E, Roldan-Hernandez CA, Martin-Ramirez A, Garcia-Collado L, Fouassier L, Vaquero J
Int J Mol Sci. 2025 Nov 18;26(22):11135. doi: 10.3390/ijms262211135
2025 
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