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Gallbladder cancer beyond genetics: tumor-immune microenvironment interactions and emerging translational therapeutic strategies

Mainardi L, Gokulanathan N, Raggi C, Koyyala VPB
Biochim Biophys Acta Rev Cancer. 2026 Oct 24:189740. doi: 10.1016/j.bbcan.2026.189740
2026 
Result from  
Results from  

Patient-Derived Organoids from cryopreserved tissue can represent clinically relevant tools for drug testing in Biliary Cancer

Rae C, O'Rourke CJ, Tesini G, Greaves J, Rink C, Nixon C, Vlachogiannis G, Munro AF, Pijnenburg D, Cardinale V, Carpino G, Cascione L, Corbo V, Amato F, Marco S, Prete MG, Rimassa L, Terracciano LM, Sandilands E, Gasparello J, McGreevy O, Quinn LM, Malik H, Verstegen MMA, Koerkamp BG, Campbell E, Kendall TJ, McHaffie SL, Guest RV, Pea A, Kay D, Elswood T, Duthie F, Dickson EJ, Coats M, McKay CJ, Holroyd D, Knight O, Al-Adhami AS, Jamieson NB, Chang DK, Orange C, Bryant DM, Morton JP, Andersen JB, Fassan M, Braconi C
JHEP Rep. 2026 Oct 26:102083. doi: 10.1016/j.jhepr.2026.102083
2026 
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Genomic and immune profiling characterizes immune heterogeneity and a TIGIT-associated subtype in intrahepatic cholangiocarcinoma

Korosteleva A, Reschke JS, Yi D, Marhenke S, Zhao J, Volk V, Reineke-Plaaß T, Peter S, Hoffmann C, Tran DDH, Gerdes C, Bathon M, Kolch W, Feuerhake F, Zhernovkov V, Saborowski A, Vogel A
Hepatol Commun. 2026 Oct 19;10(11):e1052. doi: 10.1097/HC9.0000000000001052
2026 
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"Our patients deserve better"-roadblocks to optimal care in biliary malignancies

Lamarca A, Macias I, Crespo Cruz MI, Cammarota A, Rimassa L, Bridgewater J
ESMO Open. 2026 Oct 12;11(11):108596. doi: 10.1016/j.esmoop.2026.108596
2026 
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OA Funded by  

Longitudinal liquid biopsy and matched radiomic analysis indicated resistance mechanisms of patients with biliary tract cancer undergoing systemic treatment

Tesini G, Greaves J, Ammirabile A, Cavinato L, Amato F, Rae C, Marco S, Mahdieh M, Knight O, Zanuso V, McHaffie S, Vita F, Prete MG, MacMillian A, Allan K, Herzyk P, Galbraith J, Meenan R, Henderson M, Campbell S, Lampis A, Chesler L, Fassan M, Kendall TJ, Rimassa L, Viganò L, Braconi C
Clin Cancer Res. 2026 Oct 1. doi: 10.1158/1078-0432.CCR-26-1550
2026 
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